Amphetamines exert their effect by blocking the reuptake of which two neurotransmitters?

Amphetamines exert their effect by blocking the reuptake of which two neurotransmitters?

• A. GABA and glutamate
• B. Norepinephrine and dopamine
• C. Serotonin and dopamine
• D. Acetylcholine and norepinephrine

Answer: (B)

Amphetamines produce their stimulant effects mainly by increasing the levels of two monoamine neurotransmitters in the synaptic cleft: dopamine and norepinephrine. They enter the neuron and promote release of these neurotransmitters while also blocking their reuptake, so more dopamine and norepinephrine remain available to stimulate postsynaptic receptors. This leads to heightened alertness, energy, and euphoria. GABA and glutamate are not the primary targets of amphetamines, and although some serotonin activity can occur at higher doses, the core reuptake blockade most associated with their action is on dopamine and norepinephrine. Acetylcholine is not involved here.

Amphetamines produce their stimulant effects mainly by increasing the levels of two monoamine neurotransmitters in the synaptic cleft: dopamine and norepinephrine. They enter the neuron and promote release of these neurotransmitters while also blocking their reuptake, so more dopamine and norepinephrine remain available to stimulate postsynaptic receptors. This leads to heightened alertness, energy, and euphoria.

GABA and glutamate are not the primary targets of amphetamines, and although some serotonin activity can occur at higher doses, the core reuptake blockade most associated with their action is on dopamine and norepinephrine. Acetylcholine is not involved here.